August 2025

•  
  vs
  Denver Broncos Broncos
  30-9
  Levi's Stadium
•  
  @
  Las Vegas Raiders Raiders
  22-19
  Allegiant Stadium
•  
  vs
  Los Angeles Chargers Chargers
  30-23
  Levi's Stadium

September 2025

•  
  @
  Seattle Seahawks Seahawks
  17-13
  Lumen Field
•  
  @
  New Orleans Saints Saints
  26-21
  Caesars Superdome
•  
  vs
  Arizona Cardinals Cardinals
  16-15
  Levi's Stadium
•  
  vs
  Jacksonville Jaguars Jaguars
  26-21
  Levi's Stadium

October 2025

•  
  @
  Los Angeles Rams Rams
  26-23
  SoFi Stadium
•  
  @
  Tampa Bay Buccaneers Buccaneers
  30-19
  Raymond James Stadium
•  
  vs
  Atlanta Falcons Falcons
  20-10
  Levi's Stadium
•  
  @
  Houston Texans Texans
  26-15
  NRG Stadium

November 2025

•  
  @
  New York Giants Giants
  34-24
  MetLife Stadium
•  
  vs
  Los Angeles Rams Rams
  42-26
  Levi's Stadium
•  
  @
  Arizona Cardinals Cardinals
  41-22
  State Farm Stadium
•  
  vs
  Carolina Panthers Panthers
  20-9
  Levi's Stadium
•  
  @
  Cleveland Browns Browns
  26-8
  Huntington Bank Field

December 2025

•  
  vs
  Tennessee Titans Titans
  37-24
  Levi's Stadium
•  
  @
  Indianapolis Colts Colts
  48-27
  Lucas Oil Stadium
•  
  vs
  Chicago Bears Bears
  42-38
  Levi's Stadium

January 2026

•  
  vs
  Seattle Seahawks Seahawks
  13-3
  Levi's Stadium
•  
  @
  Philadelphia Eagles Eagles
  23-19
  Lincoln Financial Field
•  
  @
  Seattle Seahawks Seahawks
  41-6
  Lumen Field