•  
  vs
  Inter Miami CF Inter Miami CF
  3-0
  Los Angeles Memorial Coliseum
•  
  vs
  Real Espana Real Espana
  1-0
  BMO Stadium
•  
  @
  Houston Dynamo Dynamo
  2-0
  Shell Energy Stadium
•  
  vs
  FC Dallas FC Dallas
  1-0
  BMO Stadium
•  
  vs
  St. Louis CITY SC St. Louis CITY SC
  2-0
  BMO Stadium
•  
  @
  Austin FC Austin FC
  0-0
  Q2 Stadium
•  
  vs
  Orlando City SC Orlando City SC
  6-0
  BMO Stadium
•  
  @
  Portland Timbers Timbers
  2-1
  Providence Park
•  
  vs
  San Jose Earthquakes Earthquakes
  4-1
  BMO Stadium
•  
  vs
  Colorado Rapids Rapids
  0-0
  BMO Stadium
•  
  @
  Minnesota United Minnesota United
  1-0
  Allianz Field
•  
  @
  San Diego FC San Diego FC
  2-2
  Snapdragon Stadium
•  
  vs
  Houston Dynamo Dynamo (+0.5)
   
  BMO Stadium
•  
  @
  St. Louis CITY SC St. Louis CITY SC (+0.5)
   
  Energizer Park
•  
  @
  Nashville SC Nashville SC (-0.5)
   
  GEODIS Park
•  
  vs
  Seattle Sounders Sounders
   
  BMO Stadium
•  
  vs
  Guadalajara Guadalajara
   
  BMO Stadium
•  
  @
  Toluca Toluca
   
  BMO Stadium
•  
  vs
  Queretaro Queretaro
   
  BMO Stadium

Knockout (Two Legs)

•  
  vs
  Alajuelense Alajuelense
  1-1
  BMO Stadium
•  
  @
  Alajuelense Alajuelense
  2-1
  Alejandro Morera Soto
•  
  vs
  Cruz Azul Cruz Azul
  3-0
  BMO Stadium
•  
  @
  Cruz Azul Cruz Azul
  1-1
  Estadio Cuauhtémoc
•  
  vs
  Toluca Toluca
  2-1
  BMO Stadium
•  
  @
  Toluca Toluca
  4-0
  Estadio Nemesio Díez Riega

Regular Season

•  
  @
  Los Angeles Galaxy Galaxy
   
  Dignity Health Sports Park
•  
  vs
  Real Salt Lake Real Salt Lake
   
  BMO Stadium
•  
  vs
  Sporting Kansas City Sporting Kansas City
   
  BMO Stadium
•  
  @
  Vancouver Whitecaps Whitecaps
   
  BC Place
•  
  vs
  San Diego FC San Diego FC
   
  BMO Stadium
•  
  @
  Colorado Rapids Rapids
   
  Dick's Sporting Goods Park
•  
  vs
  Portland Timbers Timbers
   
  BMO Stadium
•  
  @
  D.C. United D.C. United
   
  Audi Field
•  
  @
  Real Salt Lake Real Salt Lake
   
  America First Field
•  
  vs
  New York Red Bulls Red Bulls
   
  BMO Stadium
•  
  @
  Sporting Kansas City Sporting Kansas City
   
  Children's Mercy Park
•  
  @
  San Jose Earthquakes Earthquakes
   
  Levi's Stadium
•  
  @
  FC Dallas FC Dallas
   
  Toyota Stadium
•  
  vs
  Vancouver Whitecaps Whitecaps
   
  BMO Stadium
•  
  vs
  Austin FC Austin FC
   
  BMO Stadium
•  
  vs
  Los Angeles Galaxy Galaxy
   
  BMO Stadium
•  
  vs
  Minnesota United Minnesota United
   
  BMO Stadium
•  
  @
  New York City FC New York City FC
   
  Citi Field
•  
  @
  Seattle Sounders Sounders
   
  Lumen Field