•  
  vs
  Shakhtar Donetsk Shakhtar Donetsk
  0-0
  Olympic Athletic Center of Athens "Spiros Louis"
•  
  @
  Shakhtar Donetsk Shakhtar Donetsk
  0-0
  Henryk-Reyman-Stadium
•  
  vs
  Samsunspor Samsunspor
  2-1
  Olympic Athletic Center of Athens "Spiros Louis"
•  
  @
  Samsunspor Samsunspor
  0-0
  Samsun 19 Mayis
•  
  @
  Young Boys Bern Young Boys Bern
  4-1
  Stadion Wankdorf
•  
  vs
  Go Ahead Eagles Go Ahead Eagles
  2-1
  Olympic Athletic Center of Athens "Spiros Louis"
•  
  @
  Feyenoord Feyenoord
  3-1
  Stadion Feijenoord
•  
  @
  Malmö FF Malmö FF
  1-0
  Eleda Stadion
•  
  vs
  Sturm Graz Sturm Graz
  2-1
  Athens Olympic Stadium
•  
  vs
  Viktoria Plzen Viktoria Plzen
  0-0
  Olympic Athletic Center of Athens "Spiros Louis"
•  
  @
  Ferencvaros Ferencvaros
  1-1
  Groupama Arena
•  
  vs
  Roma Roma
  1-1
  Olympic Athletic Center of Athens "Spiros Louis"
•  
  vs
  Viktoria Plzen Viktoria Plzen
  2-2
  Olympic Athletic Center of Athens "Spiros Louis"
•  
  @
  Viktoria Plzen Viktoria Plzen
  1-1
  Doosan Arena

Knockout (Two Legs)

•  
  vs
  Real Betis Real Betis
  1-0
  Olympic Athletic Center of Athens "Spiros Louis"
•  
  @
  Real Betis Real Betis
  4-0
  Estadio la Cartuja