•  
  vs
  Atlanta United FC Atlanta United FC
  1-0
  Lower.com Field
•  
  @
  Minnesota United Minnesota United
  1-1
  Allianz Field
•  
  vs
  Chicago Fire Fire
  2-1
  Lower.com Field
•  
  vs
  New York Red Bulls Red Bulls
  3-0
  Lower.com Field
•  
  @
  Charlotte FC Charlotte FC
  2-0
  Bank of America Stadium
•  
  @
  Nashville SC Nashville SC
  2-2
  GEODIS Park
•  
  vs
  D.C. United D.C. United
  1-1
  Lower.com Field
•  
  @
  Real Salt Lake Real Salt Lake
  0-0
  America First Field
•  
  vs
  Portland Timbers Timbers
  2-2
  Lower.com Field
•  
  vs
  CF Montreal CF Montreal
  0-0
  Lower.com Field
•  
  vs
  FC Cincinnati FC Cincinnati (+0.5)
   
  Lower.com Field
•  
  @
  CF Montreal CF Montreal (+0.5)
   
  Stade Saputo
•  
  @
  Chicago Fire Fire
   
  Soldier Field
•  
  @
  Orlando City SC Orlando City SC
   
  Inter&Co Stadium
•  
  vs
  New England Revolution Revolution
   
  Lower.com Field
•  
  vs
  Seattle Sounders Sounders
   
  Lower.com Field
•  
  @
  New York City FC New York City FC
   
  Yankee Stadium
•  
  @
  Inter Miami CF Inter Miami CF
   
  Chase Stadium
•  
  vs
  Sporting Kansas City Sporting Kansas City
   
  Lower.com Field
•  
  @
  New England Revolution Revolution
   
  Gillette Stadium
•  
  vs
  Nashville SC Nashville SC
   
  Lower.com Field
•  
  vs
  Toronto FC Toronto FC
   
  Lower.com Field
•  
  @
  Los Angeles FC Los Angeles FC
   
  BMO Stadium
•  
  vs
  Charlotte FC Charlotte FC
   
  Lower.com Field
•  
  @
  Atlanta United FC Atlanta United FC
   
  Mercedes-Benz Stadium
•  
  @
  Philadelphia Union Union
   
  Subaru Park
•  
  vs
  New York City FC New York City FC
   
  Lower.com Field
•  
  @
  FC Cincinnati FC Cincinnati
   
  TQL Stadium
•  
  @
  Toronto FC Toronto FC
   
  BMO Field
•  
  vs
  Orlando City SC Orlando City SC
   
  Lower.com Field
•  
  @
  D.C. United D.C. United
   
  Audi Field
•  
  vs
  Inter Miami CF Inter Miami CF
   
  Lower.com Field
•  
  vs
  Philadelphia Union Union
   
  Lower.com Field
•  
  @
  New York Red Bulls Red Bulls
   
  Red Bull Arena

Knockout (Two Legs)

•  
  vs
  Monterrey Monterrey
  2-1
•  
  @
  Monterrey Monterrey
  3-1
  Estadio BBVA

Knockout

•  
  @
  Pachuca Pachuca
   
  Estadio Hidalgo