August 2025

•  
  vs
  New York Giants Giants
  34-25
  Highmark Stadium
•  
  @
  Chicago Bears Bears
  38-0
  Soldier Field
•  
  @
  Tampa Bay Buccaneers Buccaneers
  23-19
  Raymond James Stadium

September 2025

•  
  vs
  Baltimore Ravens Ravens
  41-40
  Highmark Stadium
•  
  @
  New York Jets Jets
  30-10
  MetLife Stadium
•  
  vs
  Miami Dolphins Dolphins
  31-21
  Highmark Stadium
•  
  vs
  New Orleans Saints Saints
  31-19
  Highmark Stadium

October 2025

•  
  vs
  New England Patriots Patriots
  23-20
  Highmark Stadium
•  
  @
  Atlanta Falcons Falcons
  24-14
  Mercedes-Benz Stadium
•  
  @
  Carolina Panthers Panthers
  40-9
  Bank of America Stadium

November 2025

•  
  vs
  Kansas City Chiefs Chiefs
  28-21
  Highmark Stadium
•  
  @
  Miami Dolphins Dolphins
  30-13
  Hard Rock Stadium
•  
  vs
  Tampa Bay Buccaneers Buccaneers
  44-32
  Highmark Stadium
•  
  @
  Houston Texans Texans
  23-19
  NRG Stadium
•  
  @
  Pittsburgh Steelers Steelers
  26-7
  Acrisure Stadium

December 2025

•  
  vs
  Cincinnati Bengals Bengals
  39-34
  Highmark Stadium
•  
  @
  New England Patriots Patriots
  35-31
  Gillette Stadium
•  
  @
  Cleveland Browns Browns
  23-20
  Huntington Bank Field
•  
  vs
  Philadelphia Eagles Eagles
  13-12
  Highmark Stadium

January 2026

•  
  vs
  New York Jets Jets
  35-8
  Highmark Stadium
•  
  @
  Jacksonville Jaguars Jaguars
  27-24
  EverBank Stadium
•  
  @
  Denver Broncos Broncos
  33-30
  Empower Field at Mile High