August 2025

•  
  vs
  Indianapolis Colts Colts
  24-16
  M&T Bank Stadium
•  
  @
  Dallas Cowboys Cowboys
  31-13
  AT&T Stadium
•  
  @
  Washington Commanders Commanders
  30-3
  Northwest Stadium

September 2025

•  
  @
  Buffalo Bills Bills
  41-40
  Highmark Stadium
•  
  vs
  Cleveland Browns Browns
  41-17
  M&T Bank Stadium
•  
  vs
  Detroit Lions Lions
  38-30
  M&T Bank Stadium
•  
  @
  Kansas City Chiefs Chiefs
  37-20
  GEHA Field at Arrowhead Stadium

October 2025

•  
  vs
  Houston Texans Texans
  44-10
  M&T Bank Stadium
•  
  vs
  Los Angeles Rams Rams
  17-3
  M&T Bank Stadium
•  
  vs
  Chicago Bears Bears
  30-16
  M&T Bank Stadium
•  
  @
  Miami Dolphins Dolphins
  28-6
  Hard Rock Stadium

November 2025

•  
  @
  Minnesota Vikings Vikings
  27-19
  U.S. Bank Stadium
•  
  @
  Cleveland Browns Browns
  23-16
  Huntington Bank Field
•  
  vs
  New York Jets Jets
  23-10
  M&T Bank Stadium
•  
  vs
  Cincinnati Bengals Bengals
  32-14
  M&T Bank Stadium

December 2025

•  
  vs
  Pittsburgh Steelers Steelers
  27-22
  M&T Bank Stadium
•  
  @
  Cincinnati Bengals Bengals
  24-0
  Paycor Stadium
•  
  vs
  New England Patriots Patriots
  28-24
  M&T Bank Stadium
•  
  @
  Green Bay Packers Packers
  41-24
  Lambeau Field

January 2026

•  
  @
  Pittsburgh Steelers Steelers
  26-24
  Acrisure Stadium